High–Resolution Nano–LAMP Microarrays to Measure the Binding Strength of Therapeutic Human Natural Auto–Antibodies on Target Cell–Surface Antigens
Research Team: Sang–Hyun Oh, Ph.D., University of Minnesota; and Moses Rodriguez, M.D., Mayo Clinic
The goal is to develop a nano–device to measure binding strength of antibodies on the surface of cells. The technique could impact multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and spinal cord injuries.
New Generation Oncolytic Adenovirus for Refractory Cancers
Research Team: Masato Yamamoto, M.D., Ph.D., University of Minnesota; and John Morris III, M.D., Mayo Clinic
The goal of this project is to develop viral constructs that will have clinical impact on such cancers as prostate, breast, pancreatic, esophageal and lung and bring them to the threshold of clinical trials.
Small Molecule Screens for Selective Growth Inhibitors in a Yeast Model of Familial Paraganglioma
Research Team: Gunda Georg, Ph.D., University of Minnesota; and Jim Maher, Ph.D., Mayo Clinic
The goal is to develop novel drugs that would stop small neuroendocrine tumors from becoming malignant cancers.
Cell Therapy of Cardiac Arrhythmias
Research Team: Robert Tranquillo, Ph.D., University of Minnesota; and Douglas Packer, M.D., Mayo Clinic
This team aims to discover cell–based therapies for arrhythmias and develop them for treating cardiac patients.
Towards Gene Therapy of Friedreich Ataxia and Other Mitochondrial Diseases
Research Team: Michael Koob, Ph.D., University of Minnesota; and Grazia Isaya, M.D., Ph.D., Mayo Clinic
This team has developed technology to engineer the mitochondrial genome in mammals and wants to use it to develop a gene therapy for Friedreich ataxia, a genetic neurodegenerative disease that causes muscle paralysis in the lower extremities.
Hydrogen Sulfide: From Toxic Molecule to Therapeutic Agent
Research Team: Michael Levitt, M.D., University of Minnesota; and Joseph Szurszewski, Ph.D., Mayo Clinic
The goal is to develop sulfide–based drugs to treat inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.